![]() This model has been difficult to test due to the lack of methods to selectively measure the activity of direct- and indirect-pathway SPNs in freely moving animals. ![]() The prevailing model of basal ganglia function proposes that two orthogonal projection circuits originating from distinct populations of spiny projection neurons (SPNs) in the striatum 5, 6 - the so-called direct and indirect pathways - have opposing effects on movement: while activity of direct-pathway SPNs purportedly facilitates movement, activity of indirect-pathway SPNs inhibits movement 1, 2. ![]() The basal ganglia are subcortical nuclei that control voluntary actions, and are affected by a number of debilitating neurological disorders 1– 4. ![]()
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